Apyramide 是一种抗炎试剂 (NSAID),是吲哚美辛的前药。Indomethacin 是一种强效的、血脑通透的、非选择性的 COX1 和 COX2 抑制剂。
产品描述
Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.
体内活性
Apyramide is far less toxic than indomethacin in rats and mice by the oral or the i.p. route. It exhibits anti-inflammatory activity on carrageenin-induced cotton pellet granuloma, paw oedema, and adjuvant arthritis, as well as antipyretic and analgesic activities[1].
Cas No.
68483-33-0
分子式
C27H23ClN2O5
分子量
490.93
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years