AZD-5672 是 CCR5 的拮抗剂，IC50 为 0.32 nM。 AZD-5672 抑制 HERG 心脏离子通道结合和 P-gp 介导的地高辛转运，IC50 为 7.3 μM 和 32 μM。 AZD-5672 可用于类风湿性关节炎的研究。

AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheumatoid arthritis.

In Caco-2 cells, AZD-5672 (0-100 μM) inhibits P-gp-mediated digoxin transport in a concentration-dependent manner[1].

AZD-5672 (1-2 mg/kg; i.v) shows moderate bioavailability with CI, Vss and t1/2 of 28 mL/min/kg, 5.3 L/kg, and 2.6 h in rats while 18 mL/min/kg, 5.7 L/kg, and 3.9 h in dogs[3].

780750-65-4

C32H38F2N2O5S2

632.78

AZD 5672

DMSO:30 mg/mL (47.4 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years