N-DesALKylflurazepam 是苯二氮卓类化合物 (如 Flurazepam) 的一种长效代谢物。它是 L-型电压门控钙通道的抑制剂, 对Cav1.2和Cav1.3的IC50分别为 55 μM 和 37 μM。

N-Desalkylflurazepam is a long-acting metabolite of benzodiazepine compounds, such as Flurazepam. N-Desalkylflurazepam inhibits L-type voltage-gated calcium channels with IC50 of 55 μM and 37 μM for Ca v 1.2 and Ca v 1.3 , respectively.

N-Desalkylflurazepam is the Flurazepam's long-acting metabolite that reduces the amplitudes of all the evoked potentials (EPs) components [1].

2886-65-9

C15H10ClFN2O

288.7

Norfludiazepam;N-Desalkylflurazepam

DMSO:100 mg/mL (346.38 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years