Lycobetaine acetate 是一种潜在的抗罗克福提青霉和黑曲霉的生物杀菌剂。

Lycobetaine acetate is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Ungeremine have strong antibacterial activity against Flavobacterium columnare

Ungeremine displayed cytotoxic activity towards the 9 cancer cell lines tested, including drug-sensitive and MDR phenotypes. The IC50values obtained varied from 3.67 μM (in MDA-MB-231-BCRP breast carcinoma cells) to 75.24 μM (against in CEM/ADR5000 leukemia cells) for ungeremine and from 0.02 μM (against CCRF-CEM cells) to 122.96 μM (against CEM/ADR5000 cells) for doxorubicin (control drug). Ungeremine induced ferroptosis, necroptosis, autophagy as well as apoptosis mediated by caspase activation, MMP alteration and increase ROS production[1].

The cytotoxicity, ferroptotic and necroptotic cell death were determined by the resazurin reduction assay. Caspase activation was evaluated using the caspase-Glo assay. Flow cytometry was applied for the analysis of cell cycle analysis (PI staining), apoptosis (annexin V/PI staining), mitochondrial membrane potential (MMP) (JC-1) and reactive oxygen species (ROS) (H2DCFH-DA). Apoptotic, necroptotic and autophagic markers were determined by Western blotting. CCRF-CEM leukemia cells were used for all mechanistic studies[1].

61221-41-8

C18H15NO5

325.32

Oxylycorine;氧化石蒜碱乙酸盐

DMSO:Insoluble
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years