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Arenobufagin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arenobufagin图片
CAS NO:464-74-4
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
沙蟾毒精
沙蟾毒经
产品介绍
Arenobufagin 是一种蟾蜍甾烯,从蟾蜍毒液中提取得到,具有抗癌活性。

产品描述

Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells.

体外活性

Arenobufagin induced mitochondria-mediated apoptosis in HCC cells, with decreasing mitochondrial potential, as well as increasing Bax/Bcl-2 expression ratio, Bax translocation from cytosol to mitochondria. Arenobufagin also induced autophagy in HepG2/ADM cells. Autophagy-specific inhibitors (3-methyladenine, chloroquine and bafilomycin A1) or Beclin1 and Atg 5 small interfering RNAs (siRNAs) enhanced arenobufagin-induced apoptosis, indicating that arenobufagin-mediated autophagy may protect HepG2/ADM cells from undergoing apoptotic cell death [1]. arenobufagin inhibited vascular endothelial growth factor (VEGF)-induced viability, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs) in vitro [2]. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1 [3].

体内活性

Arenobufagin inhibited the growth of HepG2/ADM xenograft tumors, which were associated with poly (ADP-ribose) polymerase cleavage, light chain 3-II activation and mTOR inhibition [1]. Arenobufagin also suppressed sprouting formation from VEGF-treated aortic rings in an ex vivo model [2].

Cas No.

464-74-4

分子式

C24H32O6

分子量

416.514

别名

沙蟾毒精;沙蟾毒经

储存和溶解度

Ethanol:1 mg/mL (24.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years