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α-Spinasterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
α-Spinasterol图片
CAS NO:481-18-5
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
alpha-Spinasterol
Α-波菜甾醇
菠甾醇
产品介绍
alpha-Spinasterol 是一种从Spinacia oleracea分离的瞬时受体电位香草酸 1 拮抗剂,具有抗菌、抗炎、抗抑郁、抗氧化和抗伤害作用。它抑制COX-1和COX-2活性,IC50值分别为 16.17 μM 和 7.76 μM。

产品描述

α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 values of 16.17 μM and 7.76 μM, respectively.

体内活性

Oral administration of α-spinasterol reduced postoperative pain, when given as a pre- (0.5 h before incision) or post-treatment (0.5 h after incision), and reduced cell infiltration in the injured tissue.?α-Spinasterol also reduced the mechanical allodynia induced by partial sciatic nerve ligation and the mechanical and cold allodynia induced by paclitaxel.?Moreover, α-spinasterol inhibited COX-1 and COX-2 enzyme activities without altering the body temperature of animals.?Importantly, α-spinasterol did not alter spontaneous or forced locomotor activity.?Furthermore, it did not cause gastric damage or liver and kidney changes, nor did it alter cell viability in the cerebral cortex and spinal cord slices of mice.

Cas No.

481-18-5

分子式

C29H48O

分子量

412.69

别名

alpha-Spinasterol;Α-波菜甾醇;菠甾醇

储存和溶解度

H2O:insoluble
DMSO:insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years