Saroglitazar 是 PPAR 的激动剂，对 PPARα 和 PPARγ 的 EC50 值为 0.65 pM 和 3 nM。

Saroglitazar is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.

In db/db mice, Saroglitazar (0.01-3 mg/kg; orally) reduces serum triglycerides, free fatty acids, and glucose in a dose-dependent manner (ED50 = 0.05, 0.19, and 0.19 mg/kg). Saroglitazar (1 mg/kg) significantly reduces serum insulin and AUC-glucose(91%)[3].

495399-09-2

C25H29NO4S

439.57

Lipaglyn

DMSO:22.5mg/mL (51.2mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years