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Ro24-7429
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ro24-7429图片
CAS NO:139339-45-0
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Ro-24-7429
Ro 24-7429
Ro 247429
产品介绍
Ro24-7429 是一种有效的口服活性 HIV-1 反式激活蛋白 Tat 拮抗剂和一种矮小相关转录因子 1 的抑制剂。Ro24-7429 具有抗 HIV、抗纤维化和抗炎作用。

产品描述

Ro24-7429 is an effective and orally active antagonist of HIV-1 transactivator protein Tat and an inhibitor of a runt-related transcription factor 1. Ro24-7429 has anti-HIV, antifibrotic, and anti-inflammatory effects.

体外活性

Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[1]. Ro 24-7429 (1-25 μM) induces apoptosis and inhibits antigen-induced lymphocyte proliferation. Ro 24-7429 (0.1 μM, 1 μM, 5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[2].

体内活性

Ro24-7429 (17.5-70 mg/kg; i.p.) curbs expression of fibrosis markers in injured mouse lungs. Ro24-7429 robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis mouse model[1].

Cas No.

139339-45-0

分子式

C14H13ClN4

分子量

272.73

别名

Ro-24-7429;Ro 24-7429;Ro 247429

储存和溶解度

DMSO:60 mg/mL?(220.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years