Bictegravir Sodium 是一种有效的 HIV-1 整合酶抑制剂，其 IC50 值为 7.5 nM。Bictegravir Sodium 表现出强大的选择性的抗 HIV 活性和低的细胞毒性。

Bictegravir Sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir Sodium exhibits potent and selective anti-HIV activity and low cytotoxicity

Bictegravir Sodium potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM, respectively, and selectivity indices (50% cytotoxic concentration [CC50]/EC50) of ~6,800 in MT-2 cells and ~1,500 in MT-4 cells[1].

1807988-02-8

C21H17F3N3NaO5

471.36

GS-9883 Sodium

DMSO:15.3mg/mL (32.5mM),ultrasonic and warming and heat to 60°C)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years