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ZLN 024 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1883548-91-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
ZLN 024 hydrochloride 是一种 AMPK 变构激活剂,可刺激无活性的 α1 亚基截短 α1 (1-394) 和 α1 (1-335),但不刺激 α1 (1-312)。

产品描述

ZLN 024 hydrochloride is an AMPK allosteric activator and stimulates the inactive α1 subunit truncations α1 (1-394) and α1 (1-335) but not α1 (1-312).

体外活性

ZLN 024 hydrochloride increases the activity of α1β1γ1 by 1.5-fold and has an EC50 of 0.42 μM, and it increases the activity of α2β1γ1 by 1.7-fold with an EC50 of 0.95 μM. ZLN 024 hydrochloride also directly activates recombinant AMPK α1β2γ1, by 1.7-fold with an EC50 of 1.1 μM; and AMPK α2β2γ1, by 1.6-fold with an EC50 of 0.13 μM. ZLN 024 hydrochloride directly activates recombinant AMPK α1β1γ1 and its homolog α2β1γ1 in a concentration-dependent manner[1].

体内活性

In C57BKS db/db mice, ZLN 024 hydrochloride(15 mg/kg/day; oral) improves glucose tolerance after 4 weeks of treatment. ZLN 024 hydrochloride reduces the fasting blood glucose by 15%. Liver tissue weight, triacylglycerol and the total cholesterol content a

Cas No.

1883548-91-1

储存和溶解度

H2O:< 0.1 mg/mL (insoluble)
DMSO:45 mg/mL (124.42 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years