Dehydroeffusol 通过选择性诱导肿瘤抑制性内质网应激和中度细胞凋亡来抑制胃癌细胞生长和致瘤性，具有抗癌、抗焦虑和镇静作用。

Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis.

Dehydroeffusol selectively activated the intracellular tumor suppressive stress response by promoting the overexpression of the key ER stress marker DNA damage-inducible transcript 3 (DDIT3), through upregulation of activating transcription factor 4 (ATF4). Concurrently, Dehydroeffusol suppressed the expression of the cell survival and ER stress marker glucose regulated protein of molecular mass 78 (GRP78) via downregulation of the transcription factor ATF6. In addition, Dehydroeffusolmarkedly activated the stress response signaling pathway MEKK4-MKK3/6-p38-DDIT3, but significantly inhibited ERK signaling[1].

137319-34-7

C17H14O2

250.29

5-Ethenyl-1-Methylphenanthrene-2,7-Diol;Dehydro Effusol;去氢厄弗酚

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years