MK-8353 是口服有效的ERK1/2选择性抑制剂，IC50分别为 23.0 nM 和 8.8 nM。它显示出抗肿瘤活性。

MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)

MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively); MK-8353 has antitumor activity.

MK-8353 causes at least 50% tumor growth inhibition or regression in 83% of the animal models bearing different tumor cells[1].

1184173-73-6

C37H41N9O3S

691.85

SCH900353

DMSO:125 mg/mL (180.68 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years