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Bisabolangelone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bisabolangelone图片
CAS NO:30557-81-4
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Bisabolangelone 是从没药中分离出来的一种倍半萜衍生物,具有抗炎作用。它通过阻断巨噬细胞内的NF-kappaB和MAPK通路抑制脂多糖刺激的炎症,具有抗溃疡作用。

产品描述

Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB signaling.

体外活性

Bisabolangelone (BISA), isolated from the roots of Angelica koreana, has many pharmacological activities, such as anti-tumor, anti-microbial, antioxidant, and anti-inflammatory activities. BISA attenuated the production of pro-inflammatory cytokines including interleukin (IL)-12, IL-1β, and tumor necrosis factor-alpha (TNF-α), migration to macrophage inflammatory protein-3 beta, and allo-T cell activating ability of DCs. In addition, BISA affected endocytosis of DCs. Molecular studies showed that BISA suppressed MAPK phosphorylation and nuclear translocation of NF-κB p50/p65. BISA inhibited DC functions by blocking MAPK and NF-κB signaling[2].

Cas No.

30557-81-4

分子式

C15H20O3

分子量

248.32

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years