Harringtonine是一种天然的 Cephalotaxus 生物碱，可抑制蛋白质合成，有抗基孔肯雅病毒活性，EC50为 0.24 μM。

Harringtonine, a natural Cephalotaxus alkaloid, inhibits protein synthesis.

Harringtonine inhibits the elongation phase of translation by preventing substrate binding to the acceptor site on the 60-S ribosome subunit and therefore block aminoacyl-tRNA binding and peptide bond formation [1]. Harringtonine displays potent inhibition of Chikungunya virus infection (EC50: 0.24 μM). Harringtonine could inhibit other alphaviruses [2]. Harringtonine inhibits the growth of human myeloid leukemia cells in vitro at low concentrations [3].

26833-85-2

C28H37NO9

531.59

三尖杉酯碱;三尖杉脂碱

DMSO:100 mg/mL (188.11 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years