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Sennoside B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sennoside B图片
CAS NO:128-57-4
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
番泻苷 B
番泻苷B
产品介绍
SenNOSide B 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷。它可通过与 PDGF-BB 及其受体结合并下调 PDGFR-β 信号传导途径来抑制 PDGF 刺激的细胞增殖。

产品描述

Sennoside B is an anthranoid. Anthranoid derivatives are used all over the world as a treatment for constipation.

体外活性

Sennoside B, a kind of irritant laxative isolated from rhei rhizome, inhibits platelet-derived growth factor (PDGF)-stimulated MG63 cell proliferation by binding to PDGF-BB and its receptor and down-regulating the PDGFR-beta signaling pathway. Pre-incubation of PDGF-BB with sennoside B inhibits the phosphorylation of pathway components including Ak strain transforming protein (AKT), signal transducer and activator of transcription 5 (STAT-5) and extracellular signal-regulated kinase 1/2 (ERK1/2). [2] It also inhibits bovine serum monoamine oxidase with IC50 of 9 μM. [1]

体内活性

LD50: Mice 5000 mg/kg (i.g.); Rats 5000 mg/kg (i.g.). [3]

Cas No.

128-57-4

分子式

C42H38O20

分子量

862.746

别名

番泻苷 B;番泻苷B

储存和溶解度

H2O:Insoluble
DMSO:91 mg/mL(105.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years