Neferine 是一种双苄基异喹啉类生物碱，可强效抑制NF-Κb激活，具有抗肿瘤活性。

1. Neferine has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.

2292-16-2

C38H44N2O6

624.778

甲基莲心碱;(R)-1,2-Dimethoxyaporphine;(-)-Neferine

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years