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L-Quebrachitol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Quebrachitol图片
CAS NO:642-38-6
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
L-白雀木醇
(-)-白雀木醇
产品介绍
L-Quebrachitol 是一种从多种植物中分离得到的天然产物,能够触发 BMP-2 反应以及 Runx2、MAPK 和 Wnt/β-CATenin 信号通路,诱导成骨细胞生成。

产品描述

L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.

体外活性

L-quebrachitol significantly promotes proliferation and cell DNA synthesis. It also enhances mineralization accompanied by increases in mRNA expression of bone matrix proteins including alkaline phosphatase (ALP), collagen type I (ColI), osteocalcin (OCN), and osteopontin (OPN). In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-κB ligand (RANKL) mRNA level. Moreover, the expression of regulatory genes associated with the mitogen-activated protein kinase (MAPK) and wingless-type MMTV integration site (Wnt)/β-catenin signaling pathways are also upregulated.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.

细胞实验

The total RNA from cells treated with l-quebrachitol was extracted using the TriPure Isolation Reagent .RNA (1 μg) was reverse transcribed using the Transcriptor First Strand cDNA Synthesis Kit to cDNA.The qRT-PCR analysis was performed using the EvaGreen HRM Mix .GAPDH was used as an internal control.The relative expression ratio was calculated using the 2^?△△Ct method.

Cas No.

642-38-6

分子式

C7H14O6

分子量

194.183

别名

L-白雀木醇;(-)-白雀木醇

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years