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Desmethylglycitein
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Desmethylglycitein图片
CAS NO:17817-31-1
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
6-羟基大豆苷元
4',6,7-三羟异黄酮
4',6,7-三羟基异黄酮
6,7,4'-Trihydroxyisoflavone
产品介绍
Desmethylglycitein 是大豆中苷元的代谢产物,具有抗氧化性和抗癌活性。它是蛋白激酶 C (PKC)α 的直接抑制剂,抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2,抑制 CDK1 和 CDK2 活性。

产品描述

6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.

体外活性

Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice.?

体内活性

A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests.?Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice

Cas No.

17817-31-1

分子式

C15H10O5

分子量

270.24

别名

6-羟基大豆苷元;4',6,7-三羟异黄酮;4',6,7-三羟基异黄酮;6,7,4'-Trihydroxyisoflavone

储存和溶解度

DMSO:125 mg/mL (462.55 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years