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(2S)-2'-Methoxykurarinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(2S)-2'-Methoxykurarinone图片
CAS NO:270249-38-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议

产品名称
2'-O-Methylkurarinone
2'-Methoxykurarinone
2'-甲氧基苦参黄素
产品介绍
2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。

产品描述

(2S)-2'-Methoxykurarinone is isolated from the roots of Sophora flavescens. (2S)-2'-Methoxykurarinone has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells.

体外活性

2'-Methoxykurarinone has strong alpha-glucosidase inhibitory activities, with IC(50) values of 155 microM. 2'-Methoxykurarinone is a noncompetitive inhibitor of protein tyrosine phosphatase 1B.

Cas No.

270249-38-2

分子式

C27H32O6

分子量

452.54

别名

2'-O-Methylkurarinone;2'-Methoxykurarinone;2'-甲氧基苦参黄素

储存和溶解度

DMSO:24 mg/mL (53.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years