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Lupiwighteone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lupiwighteone图片
CAS NO:104691-86-3
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Lupiwighteone 是一种广泛存在于野生植物中的异黄酮。它通过抑制 PI3K/Akt/mTOR 通路,诱导人乳腺癌细胞 Caspase 依赖性和非依赖性凋亡,具有抗氧化、抗菌和抗癌作用。

产品描述

Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.

体外活性

This study aimed to examine the antitumor activity of Lupiwighteone, explore its antitumor mechanism in a human prostate carcinoma cell line (DU-145), and evaluate its antiangiogenetic activity in the human umbilical vein endothelial cell line (HUVEC). The results showed that Lupiwighteone could inhibit the growth of DU-145 and HUVEC cells in a concentration-dependent and time-dependent manner by a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. Flow cytometry analysis indicated that Lupiwighteone could induce cell cycle arrest, cells apoptosis, mitochondrial membrane potential loss, and an increase in intracellular reactive oxygen species of DU-145 cells. Upregulation of Bax, cytochrome c, caspase-3, and PARP-1 protein expressions and downregulation of Bcl-2, procaspase-9, and p-Akt protein expressions were observed by western blot after the treatment of Lupiwighteone. Furthermore, the effects of Lupiwighteone on the cellular behavior of HUVECs were also investigated.

Cas No.

104691-86-3

分子式

C20H18O5

分子量

338.35

储存和溶解度

DMSO:60 mg/ml (177.33 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years