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Carbamazepine(CBZ NSC 169864)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carbamazepine(CBZ NSC 169864)图片
CAS NO:298-46-4
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)236.27
FormulaC15H12N2O
CAS No.298-46-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 47 mg/mL (198.9 mM)
Water:<1 mg/mL
Ethanol: 18 mg/mL (76.2 mM)
Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 5 mg/mL
Other info
Synonyms: NSC 169864; Carbamazepine, NSC 69864; NSC-169864; Tegretol, Epitol
IUPAC/Chemical Name: benzo[b][1]benzazepine-11-carboxamide
InChi Key: RYLOOVOCHDAWIL-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H12N2O/c16-15(18)12-9-10-5-1-3-7-13(10)17-14-8-4-2-6-11(12)14/h1-9,17H,(H2,16,18)
SMILES Code: O=C(C1=CC2=CC=CC=C2NC3=CC=CC=C13)N
实验参考方法
In Vitro

In vitro activity: Carbamazepine inhibits the binding of [3H]batrachotoxinin A 20-α-benzoate (BTX-B) to a receptor site of voltage-sensitive sodium channel with IC50 of 131 μM, to decrease the activation of sodium channel ion flux in rat brain synaptosomes. Carbamazepine reduces receptor affinity due to an increased rate of ligand dissociation from the receptor-ligand complex, without altering maximal binding capacity from the scatchard analysis of BTX-B binding to synaptosome, suggesting an indirect allosteric mechanism for anticonvulsant inhibition of BTX-B binding. Carbamazepine does not alter basal 125I-labeled scorpion toxin binding to synaptosomes in the absence of batrachotoxin, but when batrachotoxin (1.25 μM) added, Carbamazepine inhibits the batrachotoxin-dependent increase in scorpion toxin binding in a concentration-dependent manner with IC50 of 260 μM mediated at the alkaloid toxin binding site, none of which affects [3H]saxitoxin binding.

In VivoCarbamazepine at 25 mg/kg significantly increases extracellular levels of striatal and hippocampal dopamine (DA), 3,4-dihydroxyphenylalanine (DOPA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in a dose dependent manner, while Carbamazepine at 50 mg/kg significantly decreases total levels of striatal DA and DOPA as well as hippocampal HVA, but has no effect on total levels of striatal DOPAC and HVA nor on hippocampal DA, DOPA and DOPAC. Intraperitoneal administration of Carbamazepine (~100 mg/kg)to rats produces significant increases in the cerebral cortical concentrations of neuroactive steroids and neuroactive steroids in plasma in a dose and time dependent maner with DHEA formed as a result of side chain cleavage of pregnenolone not affected.
Animal modelMale Wistar rats
Formulation & DosageDissolved in saline/DMSO (50/50 vol/vol); 100 mg/kg; i.p. injection
ReferencesMol Pharmacol. 1982 Nov;22(3):627-35; Epilepsy Res. 1997 Sep;28(2):143-53.