GaNODeric acid A 能够抑制JAK-STAT3信号通路，也能抑制细胞增殖，存活率和 ROS。 它对人骨肉瘤HOS和MG-63细胞具有增殖抑制、凋亡和侵袭抑制作用。

1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis and suppression of invasion in human osteosarcoma HOS and MG-63 cells. 3. Ganoderic acid A promotes cisplatin-induced cell death by enhancing the sensitivity of HepG2 cells to cisplatin mainly via the signal transducer and activator of transcription 3 suppression, significantly suppresses IL-6-induced signal transducer and activator of transcription 3 phosphorylation.

81907-62-2

C30H44O7

516.675

灵芝酸 A;灵芝酸A

DMSO:29 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years