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Ganoderic acid C2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ganoderic acid C2图片
CAS NO:103773-62-2
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
灵芝酸 C2
产品介绍
GaNODeric acid C2 是分离自灵芝的一种三萜化合物, 具有潜在的抗肿瘤生物活性,以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose Reductase 具有很高的抑制活性,IC50为 3.8 μM。

产品描述

Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen. Ganoderic acid C2 exhibits high inhibitory activity against the rat lens aldose reductase (IC50 = 3.8 μM).

体外活性

The metabolites and pharmacokinetics of Ganoderic acid C2 (GAC2), a bioactive triterpenoid in Ganoderma lucidum in rat plasma were investigated by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Totally, ten minor phase I metabolites of GAC2 were characterized after oral administration of GAC2, on the basis of their mass fragmentation pathways or direct comparison with authentic compounds by high-performance liquid chromatography coupled with diode array detection and electrospray ion trap tandem mass spectrometry (HPLC-DAD-ESI-MS(n)), and liquid chromatography coupled with electrospray ionization hybrid ion trap and time-of-flight mass spectrometry (LC-ESI-IT-TOF/MS) methods. Moreover, a rapid and specific method for quantification of GAC2 in rat plasma after oral administration was developed by using a liquid-liquid extraction procedure and HPLC-ESI-MS/MS analysis.

Cas No.

103773-62-2

分子式

C30H46O7

分子量

518.68

别名

灵芝酸 C2

储存和溶解度

DMSO:50 mg/mL (96.40 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years