| CAS NO: | 1242184-42-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
Description: (3S,5R)-Rosuvastatin is the (3S,5R)-enantiomeric isomer of Rosuvastatin which is an anti-hyperliperdemic drug and a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels. References: [1].Watanabe,
M., et al., Synthesis and biological activity of methanesulfonamide
pyrimidine- and N-methanesulfonyl pyrrole-substituted
3,5-dihydroxy-6-heptenoates, a novel series of HMG-CoA reductase
inhibitors. Bioorg Med Chem, 1997. 5(2): p. 437-44. [2].Plante I, et al. Rosuvastatin blocks hERG current and prolongs cardiac repolarization. J Pharm Sci. 2012 Feb;101(2):868-78. [3].Feng
PF, et al. Intracellular Mechanism of Rosuvastatin-Induced Decrease in
Mature hERG Protein Expression on Membrane. Mol Pharm. 2019 Apr
1;16(4):1477-1488.
纯度：≥98%
CAS：1242184-42-4
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