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Cucurbitacin E
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cucurbitacin E图片
CAS NO:18444-66-1
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性,具有预防神经变性,具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。

产品描述

Cucurbitacin E is a natural product isolated from the climbing stem of Cucumic melo L. It significantly suppresses the activity of the cyclin B1/CDC2 complex.Cucurbitacin E has prevention of neurodegeneration, it has potent anti-proliferative, antineoplastic, anti-inflammatory and analgesic actions.

体外活性

the anti-proliferation and cell cycle G2/M arrest induced by Cucurbitacin E (CuE)?in CRC cells.?MPM-2 flow cytometry tests show that CuE-treated cells accumulated in metaphase (CuE 2.5-7.5 μM).?CuE produced G2/M arrest as well as the downregulation of CDC2 and cyclin B1 expression and dissociation.?Both effects increased proportionally with the dose of CuE;?however, the inhibition of proliferation, arrest of mitosis, production of reactive oxygen species (ROS), and loss of mitochondrial membrane potential (ΔΨm) were found to be dependent on the quantity of CuE used to treat the cancer cells.?In addition, cell cycle arrest in treated cells coincided with the activation of the gene GADD45(α, β, γ).?Incubation with CuE resulted in the binding of GADD45γ to CDC2, which suggests that the delay in CuE-induced mitosis is regulated by the overexpression of GADD45γ.?CuE may have antitumor activities in established CRC[3].

Cas No.

18444-66-1

分子式

C32H44O8

分子量

556.69

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years