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Trigonelline
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:535-83-1
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Trigenolline
葫芦巴碱
产品介绍
Trigonelline 是一种大量存在于咖啡中的生物碱,具有潜在抗糖尿病活性。它是Nrf2抑制剂,可阻断 Nrf2 依赖的蛋白酶体活性,从而增强胰腺癌细胞凋亡。

产品描述

Trigonelline, an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.

体外活性

Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9, and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells. Trigonelline significantly reduces the H2O2 induced necrosis and apoptosis in H9c2 cells. However, the further increment of Trigonelline concentration against H2O2 can induce the necrosis and apoptosis along with H2O2[1].

体内活性

Trigonelline decreases bone mineralization and tends to worsen bone mechanical properties in streptozotocin-induced diabetic rats. Trigonelline significantly increases bone mineral density (BMD) and tends to improve cancellous bone strength in nicotinamide/streptozotocin-treated rats. Trigonelline differentially affects the skeletal system of rats with streptozotocin-induced metabolic disorders like intensify the osteoporotic changes in streptozotocin-treated rats and favorably affect bones in the non-hyperglycemic (nicotinamide/streptozotocin-treated) rats[2].

Cas No.

535-83-1

分子式

C7H7NO2

分子量

137.14

别名

Trigenolline;葫芦巴碱

储存和溶解度

DMSO:10 mM
Ethanol:Insoluble
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years