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Sphondin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sphondin图片
CAS NO:483-66-9
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
6-甲氧基当归素,牛防风素
牛防风素
产品介绍
Sphondin 具有抗惊厥、抗炎和抗增殖活性,对 IL-1beta 诱导的 A549 细胞中 COX-2 蛋白水平和 PGE(2) 释放的增加具有抑制作用。

产品描述

Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.

体外活性

Sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells;?this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.?The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity. Sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation[1].

体内活性

Sphondin, showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 Μm[2].

Cas No.

483-66-9

分子式

C12H8O4

分子量

216.19

别名

6-甲氧基当归素,牛防风素;牛防风素

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years