Tetrandrine 是来自粉防己的一种双苯基异喹啉生物碱，可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。

Tetrandrine is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects.

在小鼠中,静脉注射Tetrandrine的LD50为158.9 mg/kg ,腹腔注射Tetrandrine的LD50为365 mg/kg;在大鼠中,灌胃Tetrandrine的LD50为646 mg/kg.

在大鼠神经垂体分离的神经末梢中（IC50=10.1 mM）,Tetrandrine 抑制电压门控的Ca2 +电流。Tetrandrine 是大鼠神经垂体终端maxi-Ca（2 +）激活的K +通道II型（IC50=0.21 mM）的高亲和性阻断剂。Tetrandrine还能够抑制Ca（2 +）激活的Cl-电流（IC50=5.2 mM）。在人白血病HL-60细胞中,Tetrandrine能够抑制细胞增殖,诱导细胞凋亡。

518-34-3

C38H42N2O6

622.77

粉防己碱;汉防己甲素;Fanchinine;NSC-77037;d-Tetrandrine;Sinomenine A;Hanfangchin A

DMSO:11.2 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years