ChelIDOnine 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M停滞，诱导 Caspase 依赖和非依赖性的细胞凋亡。

1. Chelidonine isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.

476-32-4

C20H19NO5

353.374

Stylophorin;Helidonine;白屈菜碱;Khelidonin

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
DMSO:5 mg/mL(14.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years