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Andropanolide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Andropanolide图片
CAS NO:869807-57-8
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
Andrographolide is a small antagonist for NF-Κb activation by covalent modifying reduced cysteine 62 of p50. It is a natural product mainly produced from the plant Andrographis.

产品描述

Andrographolide is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. It is a natural product mainly produced from the plant Andrographis.

体外活性

Andrographolide suppresses the activation of NF-κB in stimulated endothelial cells, which reduces the expression of cell adhesion molecule E-selectin and prevents E-selectin-mediated leukocyte adhesion, but has no effect on IκBα degradation, p50, and p65 nuclear translocation. Andrographolide (15 μM, 12 hours) inhibited the luciferase activities induced by TNF-α in a time-dependent manner (IC50: 10 μM).

Cas No.

869807-57-8

分子式

C20H30O5

分子量

350.45

储存和溶解度

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years