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Nerol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nerol图片
CAS NO:106-25-2
包装:1 mL
市场价:1360元

产品名称
Neryl alcohol
Cis-Geraniol
橙花醇
产品介绍
Nerol 是橙花油的一种单萜, 它通过增强 Ca2+和ROS来触发线粒体功能障碍并诱导凋亡,具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。

产品描述

Nerol is a monoterpene found in many essential oils, such as lemon balm and hop.Nerol can lessened the severity of ouabain-triggered arrhythmias in mammalian heart.

体内活性

Nerol primarily by reducing Ca2+ influx through L-type Ca2+ channel blockade lessened the severity of ouabain-triggered arrhythmias in mammalian heart.

动物实验

Guinea pigs were sacrificed by decapitation and hearts were removed and isolated left atrium mounted vertically in an organ baths containing Tyrode's solution of the following composition (mM): NaCl 120, KCl 2.7, MgCl2 0.9, NaHCO3 11.9, CaCl2 1.37, glucose 5.5, NaH2PO4 0.4, pH 7.4. The atria preparations were subsequently connected to Grass FI'-03 force displacement transducers to record changes in atrial contractile force. Each muscle was stretched to the length at which contractile force was maximal (1.0 gf). The atria were electrically paced at 1 Hz with pulses of 1.5 ms duration and stimulated by 70 V pulses. All preparations were allowed to equilibrate for 30 min until complete mechanical stabilization had been achieved. Nerol ( 97%) was freshly solubilized in 0.5% DMSO and cumulatively added to bath chambers. After each observation, muscles were washed several times and allowed to recover for 30 minutes until their mechanical function completely returned to control values. DMSO at this concentration did not show any significant effect on the variables measured (data not shown, n = 5).

Cas No.

106-25-2

分子式

C10H18O

分子量

154.253

别名

Neryl alcohol;Cis-Geraniol;橙花醇

储存和溶解度

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years