BRassinin 是一种从 B. cAMPestris 中分离出来的植物抗毒素,具有抗癌、化学预防、抗增殖和抗真菌活性。
产品描述
Brassinin (BSN) is a phytoalexin isolated from B. campestris that exhibits anticancer, chemopreventative, antiproliferative, and antifungal activities.
体外活性
In lung cancer cells, brassinin inhibits constitutive and IL-6-inducible STAT3 signaling through modulation of PIAS-3 and SOCS-3.It appears that brassinin induces apoptosis in PC-3 prostate cancer cells via the suppression of PI3K/Akt/mTOR/S6K1 signaling.
体内活性
Brassinin attenuates tumor growth in a xenograft lung cancer mouse model through modulation of E3 SUMO-protein ligase 3 (PIAS-3) and suppressor of cytokine signaling-3 (SOCS-3).
Cas No.
105748-59-2
分子式
C11H12N2S2
分子量
236.35
别名
油菜;BSN;芸苔宁
储存和溶解度
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years