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Magnocurarine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Magnocurarine图片
CAS NO:6801-40-7
包装:5 mg
市场价:1180元

产品介绍
Magnocurarine 是一种提取自Tiliacora racemosa中的天然产物。

产品描述

Magnocurarine is a natural product from Magnolia officinalis.

体外活性

The stem of Magnoliae officinalis (MO) cortex is always preliminarily processed before being applied in traditional Chinese medicine. The definite bioavailability of honokiol (HO) and magnolol (MA) in processed MO (PMO) and the effect of chemical profiling change on the pharmacokinetics of HO and MA are always a greater challenge compared with those of MO. Compared with that of MO, the pharmacokinetic profiling of HO and MA in the PMO was significantly changed and the mean Tmax of HO and MA was increased by 31 and 50% (P< 0.05), respectively; the mean AUC0-t and Cmax of HO were increased by 36 and 24% (P< 0.05), respectively. Subsequently, the chemical profiling of MO and PMO was investigated by a simple and rapid LC-Q/TOF-MS coupled with multivariate analysis method. Principal component analysis and hierarchical cluster analysis of the chromatographic data demonstrated that the chemical profiling of PMO was significantly different from that of MO. Eight marker components including six alkaloids (Magnocurarine, magnoflorine, roemerine and three unidentified peaks) and two lignans (obovatol and MA) were screened out by partial least-squares discriminant analysis.

Cas No.

6801-40-7

分子式

C19H24NO3

分子量

314.404

储存和溶解度

DMSO:55 mg/ml (174.94 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years