Sanguisorbigenin 抑制耐甲氧西林金黄色葡萄球菌,是一种天然抗菌剂。
产品描述
Sanguisorbigenin is a natural antimicrobial agent that inhibits methicillin-resistant Staphylococcus aureus (MRSA).
体外活性
Treatment of Sanguisorbigenin with sub-MIC concentrations (1.56-6.25 μg/mL) significantly inhibited the expression of blaR1, mecA, and blaZ in MRSA dose-dependently. The gene expression of mecA is remarkably reduced after the treatment of Sanguisorbigenin. The minimal inhibitory concentration values of Sanguisorbigenin against six strains of S. aureus are in the range of 12.5-50 μg/mL[1]. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting the mecA expression and decreasing PBP2a expression[1].
Cas No.
6812-98-2
分子式
C30H46O3
分子量
454.68
别名
3β-Hydroxyurs-12,19-dien-28-oic acid;Tomentosolic acid;地榆皂苷元;Ursa-12,19-dien-28-oic acid;19-Dehydroursolic acid
储存和溶解度
DMSO:60 mg/ml (127.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years