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Kobusin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kobusin图片
CAS NO:36150-23-9
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
自旋七叶素
去甲槟郎碱
产品介绍

产品描述

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-expressing FRT cells.

体外活性

In this study, we identified major volatile constituents present in different solvent fractions of Z. rhetsa bark using GC-MS analysis and isolated two tetrahydrofuran lignans (yangambin and Kobusin), a berberine alkaloid (columbamine) and a triterpenoid (lupeol) from the bioactive chloroform fraction. The solvent fractions and purified compounds were tested for their cytotoxic potential against human dermal fibroblasts (HDF) and mouse melanoma (B16-F10) cells, using the MTT assay. All the solvent fractions and purified compounds were found to be non-cytotoxic to HDF cells. However, the chloroform fraction and Kobusin exhibited cytotoxic effect against B16-F10 melanoma cells[1]

Cas No.

36150-23-9

分子式

C21H22O6

分子量

370.4

别名

自旋七叶素;去甲槟郎碱

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years