Karacoline 是发现于植物Aconitum kusnezoffii中的一种二萜生物碱，通过 NF-Κb 信号通路，抑制椎间盘退变中细胞外基质的降解。

Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.

From the ethanol extract, six feeding deterrents were isolated by bioassay-guided fractionation. The compounds were identified as chasmanine, crassicauline A, Karacoline, sachaconitine, talatisamine, and yunaconitine from their spectroscopic data. Chasmanine, talatisamine, Karacoline, and sachaconitine exhibited feeding deterrent activity against T. castaneum adults, with EC(50) values of 297.0, 342.8, 395.3, and 427.8 ppm, respectively. Yunaconitine and crassicauline A also possessed feeding deterrent activity against T. castaneum adults, with EC(50) values of 653.4 and 1134.5 ppm, respectively.

39089-30-0

C22H35NO4

377.52

DMSO:30 mg/ml (79.47 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years