Mosloflavone 从Scutellaria baicalensis Georgi中分离出的类黄酮,具有抗EV71活性。它可抑制铜绿假单胞菌的毒力和生物膜形成,有作为杀菌剂的潜力。它在病毒感染的初始阶段抑制 VP2 病毒复制和蛋白质表达,并抑制病毒 VP2 衣壳蛋白合成。
产品描述
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
体外活性
MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and ?7.8 μM, respectively,and also showed dose-dependent inhibition of TNF-α, IL-1β and iNOS levels in the supernatant of mouse macrophage cell line J774A.?MOSLOFLAVONE can be used as a starting point to discover lead structures for treatment of inflammatory and immunomodulatory diseases.
Cas No.
740-33-0
分子式
C17H14O5
分子量
298.29
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years