Doxepin D3 HCl is a deuterated form of Doxepin HCl. Doxepin HCl is an orally bioavailable tricyclic antidepressant. Doxepin HCl is a highly potent and specific histamine receptor H1 antagonist. Doxepin HCl is also a highly potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. References: [1]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.
[2]. Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.
纯度:≥98%
CAS:347840-07-7