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Senecionine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Senecionine图片
CAS NO:130-01-8
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
千里光宁
Senecionin
Aureine
Senecionan-11,16-dione, 12-hydroxy-
产品介绍
Senecionine 是一种吡咯里西啶生物碱,从Senecio vulgaris中分离得到,它对动物和人类有毒性。

产品描述

Senecionine is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.

体外活性

The cytotoxicity was greater in the absence of extracellular Ca2+ than in its presence, suggesting that alterations in intracellular Ca2+ distribution, and not an influx of extracellular Ca2+, were responsible for the Senecionine-induced hepatotoxicity [1].

体内活性

Senecionine fails to stimulate epoxide hydrase, it diminishes the activity of glutathione-s-transferase, aminopyrine demethylase and AHH [2]. Twice-weekly injections of senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth [3].

动物实验

Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4) [4].

Cas No.

130-01-8

分子式

C18H25NO5

分子量

335.4

别名

千里光宁;Senecionin;Aureine;Senecionan-11,16-dione, 12-hydroxy-

储存和溶解度

DMSO:5 mg/mL (14.91 mM)
Ethanol:1 mg/mL (2.98 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years