Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibition and apoptosis induction in human chronic myeloid leukemia K562 cells. Silybin B exhibits 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity.

The present study assessed the effects of the diastereoisomers on cell apoptosis, and compared these with their mixture, silybin, in human chronic myeloid leukemia K562 cells. Both isomers showed stronger effects on cell growth inhibition and apoptosis induction than silybin. Compared with Silybin B, silybin A showed higher effects on the production of intracellular reactive oxygen species and Ca2+.

142797-34-0

C25H22O10

482.44

水飞蓟宾B;水飞蓟宾A+B

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years