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Mollugin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mollugin图片
CAS NO:55481-88-4
包装与价格:
包装价格(元)
20 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
大叶茜草素
Rubimaillin
产品介绍
Mollugin 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-Κb 激活起抗癌疗效。

产品描述

Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF- κ B. Mollugin may be a novel therapeutic candidate for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis. Also, it has anticancer efficacy, can modulate the HER2 pathway in HER2-overexpressing Y cells with a potential role in the treatment and prevention of human breast and ovarian Y with HER2 overexpression.

Cas No.

55481-88-4

分子式

C17H16O4

分子量

284.311

别名

大叶茜草素;Rubimaillin

储存和溶解度

Chloroform, Dichloromethane, Ethyl Acetate, Acetone:Soluble
DMSO:20 mg/mL(70.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years