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8-Epidiosbulbin E acetate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
8-Epidiosbulbin E acetate图片
CAS NO:91095-48-6
包装与价格:
包装价格(元)
10 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
山药
8-表黄药子素E乙酸酯
产品介绍
8-Epidiosbulbin E acetate 是从 Dioscorea bulbifera L.中发现的呋喃类化合物,对耐多药细菌具有广谱的质粒治疗活性。

产品描述

8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci.

体外活性

A novel plasmid-curing compound was identified as 8-Epidiosbulbin E acetate (EEA) (norditerpene) on the basis of modern spectroscopic analysis and X-ray crystallography. EEA exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. EEA cured antibiotic resistance plasmids (R-plasmids) from clinical isolates of Enterococcus faecalis, Escherichia coli, Shigella sonnei and Pseudomonas aeruginosa with 12-48% curing efficiency. The reference plasmids of Bacillus subtilis (pUB110), E. coli (RP4), P. aeruginosa (RIP64) and Salmonella typhi (R136) were cured with efficiency ranging from 16% to 64%. EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective.

Cas No.

91095-48-6

分子式

C21H24O7

分子量

388.41

别名

山药;8-表黄药子素E乙酸酯

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years