产品描述
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells.
体外活性
The phytochemical investigation of the triterpenic fraction yielded nine triterpenic acids, ceanothic acid (1), Alphitolic acid (2), maslinic acid (3), 3- O-cis-coumaroyl Alphitolic acid (4), 3- O-trans-coumaroyl Alphitolic acid (5), 3- O-trans-coumaroyl maslinic acid (6), 3- O-cis-coumaroyl maslinic acid (7), betulinic acid (8), and oleanolic acid (9). In order to perform the quantitative determination of compounds 1- 9 in Z. jujuba fruits, an analytical method based on liquid chromatography coupled to mass spectrometry with ESI source and triple quadrupole analyzer (LC-ESI(QqQ)MS), using the very sensitive and selective mass tandem experiment called Multiple Reaction Monitoring (MRM), was developed and validated.Furthermore, the antiproliferative activity of compounds 1- 9 was determined on three different cultured cell lines, namely J774A.1, MCF7 and A459 cells[1]
Cas No.
19533-92-7
分子式
C30H48O4
分子量
472.7
别名
麦珠子酸
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years