CCR2 antagonist 4 是高效的、特异性的CCR2拮抗剂，对 CCR2b 的IC50为 180 nM，抑制 MCP-1 诱导的趋化作用的 IC50为 24 nM。

CCR2 antagonist 4 is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).

Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta in ApoE-deficient mice[3].

226226-39-7

C21H21ClF3N3O2

439.86

Teijin compound 1

DMSO:50 mg/mL (113.67 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years