BRD73954 是一种有效且特异性的 HDAC 抑制剂，对 HDAC6 和 HDAC8 的 IC50 分别为 36 nM 和 120 nM。

BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.

As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23 μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. [1]

1440209-96-0

C16H16N2O3

284.315

Ethanol:5.7 mg/mL (20 mM)),with gentle warming
DMSO:28.4 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years