RGFP966 是一种 HDAC3 抑制剂，IC50 为 0.08 μM，比其他 HDAC 选择性高 200 倍以上。
产品描述
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits >200-fold selectivity over other HDAC.
体外活性
In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells[2].
Cas No.
1396841-57-8
分子式
C21H19FN4O
分子量
362.408
储存和溶解度
DMSO:67 mg/mL (184.9 mM)
Ethanol:<1 mgml
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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