1,5-Isoquinolinediol 是一种多聚（ADP-核糖）合成酶抑制剂，对PARP1的IC50值为 0.39 μM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。

1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.

5154-02-9

C9H7NO2

161.16

H2O:1 mg/mL
Ethanol:20 mg/mL
DMSO:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years