Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against human HL-60, SF-295, MDA-MB-435, and HCT-8 cancer cell strains without hemolysis of mouse erythrocytes.

Here we describe the isolation of bufadienolides from the Brazilian toad Rhinella schneideri parotoid glands secretion, including: marinobufagin (1), bufalin (2), telocinobufagin (3), Hellebrigenin (4), and the atypical 20S,21R-epoxymarinobufagin (5) besides the widespread β-sitosterol (6). Starting from natural bufadienolides four derivatives were prepared: 3β-acetoxy-marinobufagin (7), 3β-acetoxy-bufalin (8), 3β-acetoxy-telocinobufagin (9), and 3β-acetoxy-20S,21R-epoxymarinobufagin (10).

465-90-7

C24H32O6

416.51

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years