Ophiopogonin D 是从麦冬的块茎中分离的一种天然产物，是罕见的天然存在的 C29甾体糖苷。它是一种 CYP2J3 诱导剂，用于炎症和心血管疾病的相关研究。

Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.

OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process.

945619-74-9

C44H70O16

855.028

麦冬皂苷D;麦冬皂苷 D

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years