ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki<150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylation (IC50: 8 nM).

In monotherapy efficacy studies ATR inhibitor 2 (VX-970, M6620) shows tumor stasis to regression in tumor models with alternative lengthening of telomeres (ALT).

1613191-99-3

C25H29F2N9O3

541.55

ATR inhibitor 2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years